Is a neuron a computer? Can we predict its behavior from the genes it expresses and the currents it carries?
If the model is built from the biology up, I think we can. That means starting with what the cell actually expresses: which ion channels, in what proportions, constrained by transcriptomics and physiology together.
If the model actually behaves like the tissue, then we can ask the harder question: what does failure look like? When the eye degenerates, when the circuit breaks down, can the model tell us where it went wrong and what would fix it?
That's what I'm building toward.